GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs111803315 | 1 | rs112476368 | chr14:59991452 | C14orf149 | chr14:59939406-59951126:- | -0.26 | -3.8 | 0.000153 | Schizophrenia |
| BRCA | cis | rs111803315 | 1 | rs112476368 | chr14:59991452 | JKAMP | chr14:59951161-59972080:+ | 0.32 | 5.6 | 2.76E-8 | Schizophrenia |
| BRCA | cis | rs1124769 | 1 | rs1124769 | chr15:51352249 | AP4E1 | chr15:51200946-51298097:+ | 0.13 | 3.99 | 7.13E-5 | Cognitive performance |
| BRCA | cis | rs1124769 | 1 | rs1124769 | chr15:51352249 | LOC100132724 | chr15:51236326-51238760:+ | 0.2 | 4.34 | 1.56E-5 | Cognitive performance |
| BRCA | cis | rs1124769 | 1 | rs1124769 | chr15:51352249 | SPPL2A | chr15:50999739-51057910:- | 0.16 | 4.63 | 4.14E-6 | Cognitive performance |
| BRCA | cis | rs11247915 | 1 | rs11247915 | chr1:26650550 | ZNF593 | chr1:26496388-26497362:+ | 0.08 | 3.7 | 0.000227 | Obesity-related traits |
| BRCA | cis | rs3796619 | 1 | rs11247973 | chr4:1094314 | CRIPAK | chr4:1385340-1389782:+ | 0.11 | 3.57 | 0.000368 | Recombination rate (males) |
| BRCA | cis | rs3796619 | 1 | rs11247973 | chr4:1094314 | KIAA1530 | chr4:1341104-1381836:+ | 0.12 | 3.92 | 9.31E-5 | Recombination rate (males) |
| BRCA | cis | rs7069346 | 1 | rs11248348 | chr10:124730840 | PSTK | chr10:124739556-124749906:+ | 0.13 | 3.51 | 0.000469 | Migraine without aura |
| BRCA | cis | rs11248850 | 1 | rs11248850 | chr16:163598 | NPRL3 | chr16:134273-188672:- | 0.13 | 3.74 | 0.000192 | Red blood cell traits |
| BRCA | cis | rs11248850 | 1 | rs11248850 | chr16:163598 | SNRNP25 | chr16:103829-107668:+ | -0.1 | -3.38 | 0.000753 | Red blood cell traits |
| BRCA | cis | rs1109501 | 1 | rs11249502 | chr4:71341161 | AMTN | chr4:71384298-71398459:+ | 0.26 | 7.57 | 7.8E-14 | Alcoholism (heaviness of drinking) |
| BRCA | cis | rs76419734 | 1 | rs112528936 | chr4:106633029 | INTS12 | chr4:106603787-106629881:- | -0.3 | -3.65 | 0.000271 | Post bronchodilator FEV1 |
| BRCA | cis | rs7818688 | 1 | rs112529587 | chr8:96060035 | C8orf38 | chr8:95908040-96088396:+ | -0.21 | -4.7 | 2.93E-6 | Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia |
| BRCA | cis | rs4864809 | 1 | rs1125349 | chr4:54515510 | LNX1 | chr4:54326439-54518682:- | 0.13 | 3.66 | 0.000266 | Beard thickness |